An experimental model of death from anaphylactic shock with compound 4880 and postmortem changes in levels of histamine in blood
✍ Scribed by Y Hieda; M Kageura; K Hara; M Takamoto; Y Fukuma; S Kashimura
- Publisher
- Elsevier Science
- Year
- 1990
- Tongue
- English
- Weight
- 713 KB
- Volume
- 45
- Category
- Article
- ISSN
- 0379-0738
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✦ Synopsis
The present study was made on an experimental animal model of a death from anaphylaxis, in which postmortem changes in levels of histamine and 1-methylhistamine, in whole blood were measured. Instead of the usual immunological method administering compound 48/80, a degranulating agent of mast cell and the effect closely resembling the immuno-reaction, resulted in reliable death in a short time. The animals that died rapidly after the injection of compound 48/80, were found to have large increases in levels of histamine and 1-methylhistamine soon after the administration. These results were similar to the results of injecting histamine exogenously. On the other hand, the animals that died after a longer time showed no increases in levels of those amines within about 24 h, but 24 hours after death histamine levels were only increased tremendously without rise in 1-MHA levels. These phenomena closely resembled those in the control animals that were treated with overdoses of Nembutal.