An experimental evaluation of the optimal method of use of streptokinase in venous thrombosis

✍ Scribed by A. M. Karmody; J. M. D. Galloway; G. E. Mavor

• Publisher: John Wiley and Sons
• Year: 1971
• Tongue: English
• Weight: 451 KB
• Volume: 58
• Category: Article
• ISSN: 0007-1323
• DOI: 10.1002/bjs.1800580414

✦ Synopsis

Abstract

Experiments have been carried out in dogs to determine the optimal method of use of streptokinase in venous thrombosis.

The experiments show that:– High-dose regional infusion is the most efficient system of producing thrombolysis.Occlusive thrombi are readily removed by this system.Low-dose regional infusions and high-dose systemic infusions are much less efficient but, in general, regional delivery is preferable when possible.

As a result of these experimental conclusions a number of patients have been successfully treated with high-dose regional infusions of streptokinase (Mavor, Bennett, Galloway, and Karmody, 1969; Mavor, Galloway, and Karmody, 1970).