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An expeditious synthesis of the C(1)-C(14) subunit of halichondrin B

โœ Scribed by Steven D. Burke; Kyung Woon Jung; Jeannie R. Phillips; Roman E. Perri

Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
286 KB
Volume
35
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The synthesis of he C(l)-C(14) segment 1 of hakhondtin B was achieved efficient&. Featured are the pinacof rearrangement of a-hydroxymesylate 0. the intramolecular Michael addition of 11, and the one-pot muftfstep mnversion of 73 to 1.

๐Ÿ“œ SIMILAR VOLUMES

A synthesis of the C1โ€“C15 domain of the
A synthesis of the C1โ€“C15 domain of the halichondrins
โœ Katrina L. Jackson; James A. Henderson; Jonathan C. Morris; Hajime Motoyoshi; An ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 125 KB

A concise route to the C1-C15 domain of the halichondrins is described. The key reaction is the conversion of a furfuryl alcohol to a pyranone. The stereocenter of this pyranone serves as the starting point for the other 8 stereocenters.