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An expeditious procedure for the synthesis of purines from aminoimidazolecarbaldehydes

✍ Scribed by Francisco Perandones; José L. Soto

Book ID
102338345
Publisher
Journal of Heterocyclic Chemistry
Year
1997
Tongue
English
Weight
208 KB
Volume
34
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Reactions of 4‐amino‐1,2‐dimethylimidazole‐5‐carbaldehyde (1) and 5‐amino‐1‐methylimidazole‐4‐car‐baldehydes 3 with nitriles, in the presence of dry hydrogen chloride afforded to the formation of purine derivatives. This constitutes a facile and versatile one‐pot synthesis of purines. The use of formamide instead of nitriles leads to the respective purines without substituents on the pyrimidine ring, 2d and 4e,f.

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