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An expeditious, environment-friendly, and microwave-assisted synthesis of 5-isatinylidenerhodanine derivatives

✍ Scribed by Abdelmounaim Safer; Mustapha Rahmouni; François Carreaux; Ludovic Paquin; Olivier Lozach; Laurent Meijer; Jean Pierre Bazureau

Book ID
111491438
Publisher
Versita
Year
2011
Tongue
English
Weight
189 KB
Volume
65
Category
Article
ISSN
0366-6352

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✦ Synopsis

Abstract

A series of nine 5-arylidenerhodanine derivatives was prepared in good yields and purity without the use of a solvent or catalyst under microwave-assisted condensation with some substituted isatins. All 5-arylidenerhodanines were evaluated as possible inhibitors of the CK1α/β, CDK5/p25, and GSK-3α/β kinases. None of them showed substantive inhibitory activity against these kinases when evaluated at the concentration of 10 μM.

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