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An expedient synthesis of an isofervenulin analogue

✍ Scribed by Andrew Bach; Xinglong Jiang; Joseph Mckenna; Kapa Prasad; Oljan Repic; Wen-Chung Shieh


Publisher
Journal of Heterocyclic Chemistry
Year
2004
Tongue
English
Weight
137 KB
Volume
41
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

An efficient approach has been developed for the synthesis of an isofervenulin analogue 1 employing a one‐pot condensation‐substitution reaction of a chlorocarboethoxytriazine (electrophile) with a urea (nucleophile). The resulting cyclization reaction resulted in the synthesis of a pyrimido‐heterocycle in good yield in either acidic or basic media. The former was assisted by utilizing trimethylsilyl chloride.


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