An expedient synthesis of 2,3-dihydro-5,6-dimethoxy-3-methylsulfonamido-1,2-benzisothiazole-1,1-dioxide via intramolecular sulfamoyl michael addition
✍ Scribed by J. P. Bassin; K. Al-Nawwar; M. J. Frearson
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2000
- Tongue
- English
- Weight
- 143 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0022-152X
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✦ Synopsis
Abstract
A simple method of introducing a sulfamoylmethyl group on carbon‐3 in 1,2‐benzisothiazole‐1,1‐dioxide is described.
📜 SIMILAR VOLUMES
## Abstract Irradiation of the dienone methyl ether **3a** furnished the unstable regioisomeric photoadducts **4a** and **5a** which on __Lewis__ acid‐catalyzed fragmentation afforded the tricyclic diketones **6,7** and **8**. The same mixture was obtained from the isobutyl ether **3b** (__Scheme 2
## Abstract magnified image Several 2–amino‐6‐(1‐aryl‐5‐methyl‐1__H__‐1,2,3‐triazol‐4‐yl)‐4‐phenylpyridine‐3‐carbonitrile have been synthesized by Tandem Michael addition/imino‐nitrile cyclization and the structures of these compounds were established by MS, IR, CHN, and ^1^H NMR spectral data. The