An excellent reagent for the removal of the t-butyldimethylsilyl protecting group
β Scribed by Roger F. Newton; Derek P. Reynolds; Mark A.W. Finch; David R. Kelly; Stanley M. Roberts
- Book ID
- 108384882
- Publisher
- Elsevier Science
- Year
- 1979
- Tongue
- French
- Weight
- 107 KB
- Volume
- 20
- Category
- Article
- ISSN
- 0040-4039
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
The alkoxide anion derived from 1-t-butyldimethylsilyl-4-hydroxymethyl-2-azetidinone (1) rearranged at -78Β°C into amide anion by N-O migration of the silyl protecting group. The occurrence of this intermediate was proved by quenching with benzyl bromide and phenethyl chloroformate, giving respective
During our investigations into the synthesis and identification of nucleosides and nucleotides we have been seeking versatile hydroxyl-blocking groups for use in the synthesis of oligonucle-