𝔖 Bobbio Scriptorium
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An excellent reagent for the removal of the t-butyldimethylsilyl protecting group

✍ Scribed by Roger F. Newton; Derek P. Reynolds; Mark A.W. Finch; David R. Kelly; Stanley M. Roberts


Book ID
108384882
Publisher
Elsevier Science
Year
1979
Tongue
French
Weight
107 KB
Volume
20
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES


Protecting group migration in the chemis
✍ StΓ©phane GΓ©rard; Jacqueline Marchand-Brynaert πŸ“‚ Article πŸ“… 2003 πŸ› Elsevier Science 🌐 French βš– 112 KB

The alkoxide anion derived from 1-t-butyldimethylsilyl-4-hydroxymethyl-2-azetidinone (1) rearranged at -78Β°C into amide anion by N-O migration of the silyl protecting group. The occurrence of this intermediate was proved by quenching with benzyl bromide and phenethyl chloroformate, giving respective