An Example of Model Structure Differences Using Sensitivity Analyses in Physiologically Based Pharmacokinetic Models of Trichloroethylene in Humans
โ Scribed by Karen A. Yokley; Marina V. Evans
- Book ID
- 107385910
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 931 KB
- Volume
- 69
- Category
- Article
- ISSN
- 1522-9602
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๐ SIMILAR VOLUMES
In this paper we present three physiologically based pharmacokinetic (PBPK) models for the systemic transport of trichloroethylene (TCE), with a focus on the adipose, or fat tissue. TCE is a widespread environmental contaminant, and has been shown to produce toxic effects in both animals and humans.
The objective of this study was to use in synergy physiologically based and empirical approaches to estimate the drug-specific input parameters of PBPK models of disposition to simulate the plasma concentration-time profile of epiroprim in human. The estimated input parameters were the tissue:plasma