An Example of a Ring Closure Yielding a 5-Methoxyoxazole in Preference to a Dihydroisoquinoline
✍ Scribed by Reeve, Wilkins; Paré, Philip J.
- Book ID
- 126058581
- Publisher
- American Chemical Society
- Year
- 1957
- Tongue
- English
- Weight
- 395 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0002-7863
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📜 SIMILAR VOLUMES
An enantioselective synthesis of the carbapenem antibiotic (+)-ps-5 is described. The starting point is the chiral Sharpless epoxyalcohol 2 which is transformed stereospecifically to the eziridine 6. Regioeelective ring-ope&ng of 6 by'LiEt Cu followed by RuQ oxidation yields the @-sulfonamide cat-bo
## Abstract The base‐induced α‐elimination of hydrogen chloride from 5‐chloromethyl‐5‐methylcyclopenta‐1, 3‐diene (**19**) produces 1‐methyltricyclo [3.1.0.0^2,6^]hexene‐3 (1‐methylbenzvalene) (**21**) together with toluene and spiro [4.2]heptadiene (**23**). A common intermediate, 5‐methylcyclopen