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An evolutionary conserved role of Wnt signaling in stem cell fate decision

✍ Scribed by Regina Teo; Frank Möhrlen; Günter Plickert; Werner A. Müller; Uri Frank


Book ID
116975408
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
960 KB
Volume
289
Category
Article
ISSN
0012-1606

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A role for Wnt signalling in self-renewa
✍ Reya, Tannishtha; Duncan, Andrew W.; Ailles, Laurie; Domen, Jos; Scherer, David 📂 Article 📅 2003 🏛 Nature Publishing Group 🌐 English ⚖ 346 KB

Haematopoietic stem cells (HSCs) have the ability to renew themselves and to give rise to all lineages of the blood; however, the signals that regulate HSC self-renewal remain unclear. Here we show that the Wnt signalling pathway has an important role in this process. Overexpression of activated bet