𝔖 Bobbio Scriptorium
✦   LIBER   ✦

An evaluation of the twofold rule for assessing a positive response in the L5178Y TK+/− mouse lymphoma assay

✍ Scribed by T.J. Oberly; W.P. Hoffman; M.L. Garriott

Book ID
117331648
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
676 KB
Volume
369
Category
Article
ISSN
0165-1218

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

High concentrations of sodium chloride i
High concentrations of sodium chloride induce a “positive” response at the tk locus of l5178y/tk± mouse lymphoma cells
✍ Moore, Martha M. ;Brock, Karen H. 📂 Article 📅 1988 🏛 Wiley (John Wiley & Sons) ⚖ 187 KB

One of the mammalian cell gene-mutation assays that has been used extensively for mutagenicity studies is the L5178Y/TK+'--3.7.2C mouse lymphoma assay Oberly et al., 19841. This assay measures forward mutation at the functionally heterozygous thymidine kinase (rk) locus based on resistance to trifl

Development of an optimal S9 activation
Development of an optimal S9 activation mixture for the L5178Y TK+/− mouse lymphoma mutation assay
✍ Jenness B. Majeska; Dale W. Matheson; H. E. Holden 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 667 KB

In previously described activation systems [Clive D, Spector : Mutat Res 31:17-291 for the mouse lymphoma mutation assay the cofactor isocitrate is rapidly exhausted and the resultant loss of NADPH can halt metabolic processes. Presented here are data obtained with a nontoxic b'olance of NADP (1.4 m