𝔖 Bobbio Scriptorium
✦   LIBER   ✦

An evaluation of the mechanism of action of pentamidine isethionate

✍ Scribed by Richard S. Bornstein; J. W. Yarbro

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
335 KB
Volume
2
Category
Article
ISSN
0022-4790

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✦ Synopsis

The effect of pentamidine on DNA, RNA, phospholipid, and protein synthesis was evaluated in 6C3HED ascites tumor of C3H mice by incorporation in vitro of 3Hthymidine, 3H-uridine, 3H-algal protein hydrolysate, and 32P-orthophosphate. Inhibition of all parameters measured was observed, suggesting that pentamidine does not, as has been suggested, selectively inhibit DNA synthesis or act as an antifol. A reduced incorporation of 32P into charcoal adsorbable acid soluble phosphate was observed, suggesting that pentamidine may impair nucleotide formation.

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