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An essential role of NFκB in tyrosine kinase signaling of p38 MAP kinase regulation of myocardial adaptation to ischemia

✍ Scribed by Nilanjana Maulik; Motoaki Sato; Brendan D. Price; Dipak K. Das

Book ID: 117109297
Publisher: Elsevier Science
Year: 1998
Tongue: English
Weight: 167 KB
Volume: 429
Category: Article
ISSN: 0014-5793
DOI: 10.1016/s0014-5793(98)00632-2

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## Abstract Blood vessel injury results in limited oxygen tension and diffusion leading to hypoxia, increased anaerobic metabolism, and elevated production of acidic metabolites that cannot be easily removed due to the reduced blood flow. Therefore, an acidic extracellular pH occurs in the local mi