An essential role for transmembrane TNF in the resolution of the inflammatory lesion induced by Leishmania major infection

The resolution of lesions induced by Lei

The resolution of lesions induced by Leishmania major in mice requires a functional Fas (APO-1, CD 95) pathway of cytotoxicity

✍ Fatima Conceição-Silva; Michael Hahne; Michael Schröter; Jacques Louis; Jürg Tsc 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 153 KB 👁 2 views

Normal or perforin-deficient C57BL/6 mice are able to heal spontaneously cutaneous lesions induced by Leishmania major. In this report, we show that syngeneic gld and lpr mice, lacking a functional Fas system, fail to heal their lesions. This inability to control infection could not be attributed ei