An epitope-tagging system for studying regulation of the peroxisome proliferator activated receptor alpha (PPARα)
✍ Scribed by J. M. Owens; J. D. Tugwood; G. G. Gibson
- Book ID
- 105731835
- Publisher
- Springer-Verlag
- Year
- 1997
- Tongue
- English
- Weight
- 704 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0378-7966
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## Abstract Peroxisome proliferator‐activated receptor alpha (PPARα) is a member of the nuclear hormone receptor superfamily that can be activated by natural fatty acids and various xenobiotics, including clofibrate. This transcription factor primarily regulates genes involved in lipid metabolism a
In order to identify the critical structural feature(s) of phenylpropanoic acid-type PPARalpha agonists, such as KCL, which exhibit human peroxisome proliferator-activated receptor alpha (PPARalpha)-selective activation, transient transactivation assay of KCL and related derivatives was performed wi