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An epigenetic vaccine model active in the prevention and treatment of melanoma

✍ Scribed by A Nazmul H Khan; William J Magner; Thomas B Tomasi


Book ID
119905474
Publisher
BioMed Central
Year
2007
Tongue
English
Weight
829 KB
Volume
5
Category
Article
ISSN
1479-5876

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Background. The authors have demonstrated that immunization with melanoma whole-cell vaccine (MCV) augments T-cell responses to melanoma and that cytotoxic T-cells (CTL) recognize allogeneic melanoma-bearing shared HLA-A antigens. A preclinical model was developed to assess CTL activation in vitro u