An Enzymatic Activity in Bovine Brain That Catalyzes the Reversal of the C-Terminal Methyl Esterification of Protein Phosphatase 2A

An RNA Aptamer That Selectively Inhibits

An RNA Aptamer That Selectively Inhibits the Enzymatic Activity of Protein Tyrosine Phosphatase 1B in vitro

✍ Brent Townshend; Isabelle Aubry; Richard C. Marcellus; Kalle Gehring; Michel L. 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 412 KB 👁 2 views

## Abstract __SELEX was used to create an RNA aptamer targeted to protein tyrosine phosphatase 1B (PTP1B), an enzyme implicated in type 2 diabetes, breast cancer and obesity. We found an aptamer that strongly inhibits PTP1B in vitro with a__ K__~i~ of less than 600 pM. This slow‐binding, high‐affin