An Enteric Compression Coating IV**Lilly Laboratory for Clinical Research, Indianapolis General Hospital, Indianapolis, Ind.

✍ Scribed by Ridolfo, Anthony S. ;Gruber, Charles M. ;Carmichael, Ralph C.

• Publisher: Elsevier
• Year: 1958
• Weight: 180 KB
• Volume: 47
• Category: Article
• ISSN: 0095-9553
• DOI: 10.1002/jps.3030471212

✦ Synopsis

l)-cember 1958 SCIENTIFIC EDITION 869 disintegration of the tablet after passing iuto the iutcstine. Thus, the results of the in vitro tests are supported by these in vivo studies.

U'hen single tablets containing 250 mg. of erythromycin base enclosed within an enteric cornpression coating were administered to fasting patients, a minimum therapeutic concentration of 4 mg. of erythromycin per 10 ml. of serum developed in about two hours. This therapeutic concentration was maintained for approximately nine hours.

Conclusions

1. An enteric compression coating will protect erythromycin tablet cores from deactivation by gastric fluid.

This coating dissolves rapidly after passing through t h e pylorus and liberates the erythromycin from the tablet cores.