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An enhanced active efflux of CPT-11 and SN-38 in cisplatin-resistant human KB carcinoma cells

โœ Scribed by Zhe-Sheng Chen; Tomoyuki Sumizawa; Tatsuhiko Furukawa; Kenji Ono; Ayako Tani; Masaharu Komatsu; Shin-ichi Akiyama


Book ID
117469345
Publisher
Elsevier Science
Year
1999
Tongue
English
Weight
251 KB
Volume
138
Category
Article
ISSN
0304-3835

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## Abstract Tumor cells chronically exposed to cisplatin (cDDP) acquire cDDP resistance that impacts tumor therapy. To elucidate the mechanism of acquired cDDP resistance (ACR), we compared HeLa cells that gained ACR upon chronic cDDP treatment with the parental strain. We show that ACR is due to a