Defects in the RAD52 gene of the yeast Saccharomyces cerevisiae reduce the levels of the NUC2 endo-exonuclease by approximately 90% compared to the levels in wild-type strains. To examine the potential role of this nuclease in the induction of mitochondrial 'petite' mutations, congenic RAD52 and rad
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An endo-exonuclease activity of yeast that requires a functional RAD52 gene
β Scribed by Chow, Terry Y. -K. ;Resnick, Michael A.
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 799 KB
- Volume
- 211
- Category
- Article
- ISSN
- 0026-8925
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DNA analysis of a male propositus with ornithine transcarbamylase (OTC) deficiency documented an A-to-C substitution in position +4 of intron 1. No other abnormalities were observed in the OTC gene, or at 563 bp upstream of the 5' site, which included a promoter region, or at 383 bp downstream of th