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An enantiospecific formal total synthesis of (−)-aplysin and (−)-debromoaplysin

✍ Scribed by A Srikrishna; N.Chandrasekhar Babu

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
54 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

An enantiospecific approach to marine sesquiterpenes (-)-debromoaplysin and (-)-aplysin, starting from (R)-limonene employing a Claisen rearrangement as the key step, is described.

📜 SIMILAR VOLUMES

ChemInform Abstract: An Enantiospecific
ChemInform Abstract: An Enantiospecific Formal Total Synthesis of (-)-Aplysin and (-)-Debromoaplysin.
✍ A. Srikrishna; N. Chandrasekhar Babu 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 29 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v

Total syntheses of aplysin and debromoap
Total syntheses of aplysin and debromoaplysin using a diastereoselective, sulfur mediated radical cyclisation strategy
✍ David C Harrowven; Matthew C Lucas; Peter D Howes 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 126 KB

Total syntheses of two marine sesquiterpenes, aplysin I and debromoaplysin 2, are described. The key step involves a diastereoselective, sulfur mediated radical cyclisation of diene 5 to 7 which simultaneously creates the stefically demanding aplysin skeleton and establishes the relative configurati