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An enantioselective synthesis of the core unit of the non-nucleoside reverse transcriptase inhibitor taurospongin A

✍ Scribed by Arun K. Ghosh; Hui Lei

Book ID
104359665
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
128 KB
Volume
14
Category
Article
ISSN
0957-4166

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✦ Synopsis

An enantioselective formal synthesis of taurospongin A has been achieved. The key steps involve chelation-controlled reductions of Ξ²-ketosulfoxide and Ξ²-hydroxy ketone intermediates and Sharpless asymmetric epoxidation to construct the tertiary alcohol stereoselectively.

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