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An enantioselective approach to (−)-platencin via catalytic asymmetric intramolecular cyclopropanation

✍ Scribed by Sho Hirai; Masahisa Nakada


Publisher
Elsevier Science
Year
2010
Tongue
French
Weight
498 KB
Volume
51
Category
Article
ISSN
0040-4039

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First catalytic asymmetric hydrophosphon
✍ Harald Gröger; Yoshinobu Saida; Shigeru Arai; Jürgen Martens; Hiroaki Sasai; Mas 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 160 KB

The catalytic and enantioseleetive hydrophosphonylation of a cyclic imine, namely the 3thiazoline I, is described. We have discovered a highly efficient enantioselective de novo approach to the pharmaceutically interesting 4-thiazolidinylphosphonate 2 using either titanium or lanthanoid chiral catal