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An Enantio- and Diastereoselective Synthesis of Fluorinated β-Aminoalkyloxepin Derivatives Through Mannich and Ring-Closing Metathesis Reactions.

✍ Scribed by Santos Fustero; Elisabet Esteban; Juan F. Sanz-Cervera; Diego Jimenez; Fatemeh Mojarrad


Publisher
John Wiley and Sons
Year
2007
Weight
27 KB
Volume
38
Category
Article
ISSN
0931-7597

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Powerful probes for revealing the workings of biological systems can be prepared through the judicious replacement of hydrogen atoms with fluorine. [1] The C À F bond has a significant effect on the reactivity, stability, and bioavailability of molecules. [2] Thus, there is a strong demand for a wid