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An electrophysiological study of 9-amino-1,2,3,4-tetrahydroacridine (THA) on sino-atrial node preparations of rabbits

โœ Scribed by Kotake, Hiroshi; Noguchi, Noriyasu; Doi, Tetsuya; Matsuoka, Satoshi; Hisatome, Ichiro; Hasegawa, Junichi; Mashiba, Hiroto


Book ID
121959606
Publisher
Elsevier Science
Year
1990
Tongue
English
Weight
296 KB
Volume
21
Category
Article
ISSN
0306-3623

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We have investigated the action of 9-amino-1, 2, 3, 4-tetrahydroacridine (THA) on the pacemaker current If in rabbit sino-atrial node myocytes and in canine Purkinje fibers. THA at concentrations in the range 3-300 microM blocked If in a voltage-independent manner, as revealed by measurements on the