An electroanalytical study of the anticancer drug dacarbazine

✍ Scribed by A.J.Miranda Ordieres; A.Costa Garcia; P.Tuñón Blanco; W.Franklin Smyth

• Book ID: 104100329
• Publisher: Elsevier Science
• Year: 1987
• Tongue: English
• Weight: 569 KB
• Volume: 202
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/s0003-2670(00)85909-7

✦ Synopsis

The electrochemical behaviour of dacarbazine [ 5-(3,3-dimethyl-1-triazenyl) imidazole-4-carboxamide; DTIC] was investigated by Tast and differential pulse polarography (d.p.p.) at the dropping mercury electrode, by cyclic and differential pulse voltammetry at the hanging mercury drop electrode and by anodic voltammetry at the glassy carbon electrode. Calibration graphs were obtained for 2~ 10-'-2X lob5 M DTIC by d.p.p., for 5~ 10-'-l X 10e5M by adsorptive stripping voltammetry at a hanging mercury drop electrode, and for 1-10X 10e5 M by high-performance liquid chromatography with oxidative amperometric detection at a glassy carbon electrode. The methods are compared and applied to determine DTIC added to blood serum after a simple cleanup procedure.

OTIC AIC