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An elastic model of the large-scale structure of duplex DNA

✍ Scribed by Craig J. Benham

Publisher
Wiley (John Wiley & Sons)
Year
1979
Tongue
English
Weight
749 KB
Volume
18
Category
Article
ISSN
0006-3525

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✦ Synopsis

Abstract

A general model for the large‐scale, time‐independent structure of duplex DNA is developed based on elastic considerations. The general conditions of elastic equilibrium are given. These equations are solved for the equilibrium shape of stressed duplex DNA, based on the assumption that the double helix behaves mechanically as a symmetric, linearly elastic rod. It is shown that, in general, two orders of superhelicity will arise at equilibrium. Several possible applications of this approach to the supercoiling of closed circular DNA are described.

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