An Efficient Synthesis of Okadaic Acid. -The synthesis of the title compound (I) involves the sequential coupling of the three fragments C1-C14, C16-C27, and C28-C38 of the natural product with 26 steps in the longest linear sequence of the synthesis. -(FORSYTH, C.
โฆ LIBER โฆ
An Efficient Total Synthesis of Okadaic Acid
โ Scribed by Forsyth, Craig J.; Sabes, Steven F.; Urbanek, Rebecca A.
- Book ID
- 125545048
- Publisher
- American Chemical Society
- Year
- 1997
- Tongue
- English
- Weight
- 236 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0002-7863
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## Abetract Three segments A, B and C for okadaic acid synthesis were coupled with each other in the order of At(BtC), the key steps of the twice couplings being between sulfone carbanions and aldehydea. After the BtC coupling, the asymmetric center C-27 was generated by a hydride reduction of the
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