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An efficient, three-component synthesis of spiro[benzo[g]chromene-4,3′-indoline]-3-carbonitrile and spiro[indoline-3,5′-pyrano[2,3-d]pyrimidine]-6′-carbonitrile derivatives
✍ Scribed by Ramin Ghahremanzadeh; Tayebeh Amanpour; Ayoob Bazgir
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 2009
- Tongue
- English
- Weight
- 91 KB
- Volume
- 46
- Category
- Article
- ISSN
- 0022-152X
- DOI
- 10.1002/jhet.240
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✦ Synopsis
Abstract
magnified image Spiro[benzo[g]chromene‐4,3′‐indoline]‐3‐carbonitriles and spiro[indoline‐3,5′‐pyrano[2,3‐d]pyrimidine]‐6′‐carbonitriles were synthesized via a three‐component reaction of isatins, 2‐hydroxynaphthalene‐1,4‐dione or 2‐methylpyrimidine‐4,6‐diol, and malononitrile in aqueous media. J. Heterocyclic Chem., (2009).
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## Abstract magnified image An environmentally benign three‐component reaction in aqueous media has been reported for the synthesis of spiro[indole‐3,8′‐phenaleno[1,2‐__b__]pyran]‐9′‐carbonitriles and spiro[indole‐3,4′‐pyrano[4,3‐__b__]pyran]‐3′‐carbonitriles. J. Heterocyclic Chem., (2010).