An Efficient Synthetic Strategy for the Preparation of 2, 3, 6, 7-Tetrahydro-3-phenyl-4H-oxazolo[3, 2-a]-1, 3, 5-triazin-2, 4-diones
β Scribed by I. FORFAR; J. J. BOSC; J. M. LEGER; C. JARRY
- Book ID
- 118110716
- Publisher
- Pharmaceutical Press
- Year
- 1998
- Tongue
- English
- Weight
- 369 KB
- Volume
- 4
- Category
- Article
- ISSN
- 2042-7158
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## Abstract The reaction of 2βaminoβ2βoxazolines with ethoxycarbonyl isocyanate was investigated in order to access to fused 1,3,5βtriazineβ2,4βdiones with a potential 5βHT~2~ antagonist activity. The reaction leads to 2,3,6,7βtetrahydroβ4__H__βoxazolo[3,2β__a__]β1,3,5βtriazineβ2,4βdiones and to 1β
Z-Substituted-1,2,3,4,5,6-hexahydro-3-bemwxine-4, 6diones(la-d) and 2-methoxy-2,5,6,7-tetrahydro+ benxamnine-1,3dione 8 were synthesii thro@ an oxklative ring expansion reaction of 6-methylthio-7-substiituted-benzo(a] octem (2a-d ) and 7-methylthio%-methoxy-benzo[a]nonem 7 with sodium periodate in i