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An efficient synthesis of the Prelog-Djerassi lactone methyl ester from (-)-trans-pulegenic acid

✍ Scribed by Salih Hacini; Maurice Santelli

Publisher: Elsevier Science
Year: 1990
Tongue: French
Weight: 403 KB
Volume: 46
Category: Article
ISSN: 0040-4020
DOI: 10.1016/s0040-4020(01)90075-4

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✦ Synopsis

The (+)-Prelog-Djetassi lactone methyl ester 1 was obtained from tmns-pulegenic acid 2 in seven steps jn 22 % overall YjeJd; three more steps from an unwanted dkstereoisomergave additionnal5 %. Resume : L 'ester methylique de la Iactone de Prelog-Djemssi I a et6 obtenu en sept &apes i partir de I 'acide pulegenique 2 avec un rendement global de 22 %; le traitement en trois &apes d'un diastereoisomere non souhaite foumit 5 % supplementaire.

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