A concise cnantioselective synthesis of (3S,6S,9S)-2-oxo-3-(N-Boc-amino)-lazabicyclo[4.3.0]nonane-9-carboxylic acid methyl ester from N-protected glutamic acid is described. O 1997 Elsevier Science Ltd.
An Efficient Synthesis of the Constrained Peptidomimetic 2-Oxo-3-( N -9-fluorenyloxy-carbonylamino)-1-azabicyclo[4.3.0]nonane-9-carboxylic Acid from Pyroglutamic Acid
β Scribed by Mandal, Pijus Kumar; Kaluarachchi, Kumar K.; Ogrin, Douglas; Bott, Simon G.; McMurray, John S.
- Book ID
- 120075792
- Publisher
- American Chemical Society
- Year
- 2005
- Tongue
- English
- Weight
- 97 KB
- Volume
- 70
- Category
- Article
- ISSN
- 0022-3263
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A diastereoseletvive synthesis of a peptidic tetrahydropyridazinone 10 from (S)-phenylalanine is reported. This derivative was then converted to the bicyclic peptidomimetic 11, an important class of b-strand mimetic.