An efficient synthesis of S-γ-[(4-trifluoromethyl)-phenoxy]benzenepropanamine-[1-14C] maleate, an important metabolite of fluoxetine hydrochloride

An enantioselective synthesis of S-γ-[(4

An enantioselective synthesis of S-γ-[(4-trifluoromethyl)phenoxy]benzenepropanamine-[3-14C] hydrochloride, an important metabolite of fluoxetine hydrochloride

✍ William J. Wheeler 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 French ⚖ 472 KB

## Abstract The __S__‐enantiomer of γ‐[(4‐trifluoromethyl)phenoxy]benzenepropanamine‐[3‐^14^C] hydrochloride has been prepared in eight steps from acetophenone‐[carbonyl‐^14^C]. The key step in the synthesis involved the enantioselective reduction of __R__‐2‐chloroacetophenone‐[1‐^14^C] with (‐)‐di