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An efficient synthesis of quinoxaline derivatives mediated by stannous chloride

✍ Scribed by Da-Qing Shi; Guo-Lan Dou; Sai-Nan Ni; Jing-Wen Shi; Xiao-Yue Li


Publisher
Journal of Heterocyclic Chemistry
Year
2008
Tongue
English
Weight
208 KB
Volume
45
Category
Article
ISSN
0022-152X

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✦ Synopsis


Abstract

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Various biologically important quinoxaline derivatives were efficiently synthesized in excellent yields by the reaction of 1,2‐diketones and 2‐nitroaniline, benzofuroxan or 1,2‐dinitrobenzene promoted by SnCl~2~2H~2~O. The role of stannous chloride is acting as both reductive agent and catalyst in this synthesis. This new method has the advantages of accessible starting materials, convenient manipulation, short reaction time and high yields.


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