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An efficient synthesis of pyrido[2,3-d]pyrimidine derivatives in ionic liquid

✍ Scribed by Da-Qing Shi; Yao Zhou; Hai Liu

Publisher: Journal of Heterocyclic Chemistry
Year: 2010
Tongue: English
Weight: 80 KB
Volume: 47
Category: Article
ISSN: 0022-152X
DOI: 10.1002/jhet.281

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✦ Synopsis

Abstract

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A series of 5,7‐diarylpyrido[2,3‐d]pyrimidine‐2,4(1__H__,3__H__)‐diones was synthesized via the reaction of 6‐aminopyrimidine‐2,4‐dione and α,β‐unsaturated ketones in ionic liquid without using any catalyst. This protocol has the advantages of easier work‐up, milder reaction conditions, high yields, and environmentally benign procedure over traditional methods. J. Heterocyclic Chem., 2010.

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