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An efficient synthesis of polysubstituted tetrahydrofuran and indene derivatives via the Lewis acid-mediated cycloadditions of VCPs with aldehydes

✍ Scribed by Chenliang Su; QingYang Liu; Yong Ni; Xian Huang

Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 281 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.05.038

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✦ Synopsis

A variety of polysubstituted tetrahydrofuran and indene derivatives were prepared in moderate to excellent yields via the cycloadditions of vinylidenecyclopropanes with common aldehydes in the presence of Lewis acid. The polysubstituted tetrahydrofuran 3 could undergo further transformations to the indene product 4 and furan derivatives 5.

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