✦ LIBER ✦

An efficient synthesis of optically active metabolites of platelet adhesion inhibitor OPC-29030 by lipase-catalyzed enantioselective transesterification

✍ Scribed by Kazuyoshi Kitano; Jun Matsubara; Tadaaki Ohtani; Kenji Otsubo; Yoshikazu Kawano; Seiji Morita; Minoru Uchida

Book ID: 104261729
Publisher: Elsevier Science
Year: 1999
Tongue: French
Weight: 245 KB
Volume: 40
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(99)00946-6

No coin nor oath required. For personal study only.

✦ Synopsis

Aletraa:. The optically active metabolites of (S)-3,4-dihydro-6-[3-(1-o-tolyl-2-imidazolyl)sulfmylpropoxy]-2(I/-/)-qninolinone (OPC-29030, 1), which is a new anti-platelet agent (platelet adhesion inhibitor), were effectively synthesized by the enzyme-catalyzed enantinselective transesterificatinn of the racemic sulfinyl metabolites. The enzymes can recognize a sterengenic sulfur atom remote from the reaction site.

📜 SIMILAR VOLUMES

ChemInform Abstract: Synthesis of a Key

ChemInform Abstract: Synthesis of a Key Intermediate, (S)-2-[(3-Hydroxypropyl)sulfinyl]-1-(o-tolyl)imidazole, for the Platelet Aggregation Inhibitor, OPC-29030 via Lipase-Catalyzed Enantioselective Transesterification.

✍ S. MORITA; J. MATSUBARA; K. OTSUBO; K. KITANO; T. OHTANI; Y. KAWANO; M. UCHIDA 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

Enantioselective Ring Opening of Epoxide

Enantioselective Ring Opening of Epoxides with 4-Methoxyphenol Catalyzed by Gallium Heterobimetallic Complexes: An Efficient Method for the Synthesis of Optically Active 1,2-Diol Monoethers

✍ Takehiko Iida; Noriyoshi Yamamoto; Shigeki Matsunaga; Hee-Gweon Woo; Masakatsu S 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 105 KB 👁 2 views

ChemInform Abstract: Enantioselective Ri

ChemInform Abstract: Enantioselective Ring Opening of Epoxides with 4-Methoxyphenol Catalyzed by Gallium Heterobimetallic Complexes: An Efficient Method for the Synthesis of Optically Active 1,2-Diol Monoethers.

✍ T. IIDA; N. YAMAMOTO; S. MATSUNAGA; H.-G. WOO; M. SHIBASAKI 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 34 KB 👁 2 views

## Abstract ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable v