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An Efficient Synthesis of Optically Active (2R,3R)-2-Methyl-3-[(1R)-1-methylprop-2-enyl]cyclopentanone, a Useful Chiral Building Block for Synthesis of Vitamin D and Steroids.

✍ Scribed by Yongcheng Song; Sentaro Okamoto; Fumie Sato


Publisher
John Wiley and Sons
Year
2003
Weight
16 KB
Volume
34
Category
Article
ISSN
0931-7597

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The preparative separation of the enantiomers of the title compound, a versatile chiral building block for the synthesis of unnatural amino acid esters, by high performance liquid chromatography on a chiral stationary phase (CSP), is reported for the first time. The CSP consists of amylose-(3,5-dime