## Abstract For Abstract see ChemInform Abstract in Full Text.
An efficient synthesis of novel deoxy phospha sugar pyrimidine nucleosides
β Scribed by Mitsuji Yamashita; Valluru Krishna Reddy; Putta Mallikarjuna Reddy; Yukihiro Kato; Buchammagari Haritha; Kazumitsu Suzuki; Masaki Takahashi; Tatsuo Oshikawa
- Publisher
- Elsevier Science
- Year
- 2003
- Tongue
- French
- Weight
- 199 KB
- Volume
- 44
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
An efficient method is described in the synthesis of several novel deoxy phospha sugar pyrimidine nucleosides in racemic form, analogs of normal sugar nucleosides, in high yields by treatment of (Β±)-2-aminophospholane 1-oxide with several, a-cyano-, -acetyl-, -ethoxycarbonyl-b-ethoxy-N-ethoxycarbonylacrylamides.
π SIMILAR VOLUMES
Synthesis of the title compounds can be achwed by nucleophlhc ad&tton of lithmm salts of TMSacetylene and I-hexyne to 2'-ketoundme followed by ra&cal deoxygenatlon of the correspondmg methoxaryl ester