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An efficient synthesis of N-hydroxy-α-amino acid derivatives of high optical purity

✍ Scribed by R.W Feenstra; E.H.M Stokkingreef; R.J.F Nivard; H.C.J Ottenheijm


Publisher
Elsevier Science
Year
1987
Tongue
French
Weight
270 KB
Volume
28
Category
Article
ISSN
0040-4039

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✦ Synopsis


Conversion of cc-hydroxy esters via triflates into compounds 2 proceeds in chemical yields ranging from 78 to 89% and with optical purities ranging from 76 to 100%.


📜 SIMILAR VOLUMES


A versatile asymmetric synthesis of α-am
✍ Stephen Hanessian; Youssef L. Bennani 📂 Article 📅 1990 🏛 Elsevier Science 🌐 French ⚖ 312 KB

A general protocol for the synthesis of a-amino-a-alkyl phosphonic acids in either enantiomeric form is described based on the alkylation of chiral bicyclic phosphonamides derived from (R,R)and (S,S)-1,2diaminocyclohexane. 2 CSu Br(CH&Br. 2. NaN,, DMF,140% Me Y Es& 70-75% (4) 4 h., 95%. (3) 2 Y= Cl