✦ LIBER ✦
An efficient synthesis of mixed acid phospholipids using 1-palmitoyl-sn-glycerol-3-phosphoric acid bromoalkyl esters
✍ Scribed by Hansjörg Eibl
- Book ID
- 103036999
- Publisher
- Elsevier Science
- Year
- 1980
- Tongue
- English
- Weight
- 467 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0009-3084
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✦ Synopsis
The preparation of mixed-acid phospholipids is possible in high yields from 1,2-dipalmitoylsn-glycerol-3-phosphoric acid bromoalkyl esters. The fatty acid in the 2-position of these general intermediates for phospholipid synthesis was completely removed by hydrolysis with phospholipase A2. The resulting l-palmitoyl-sn-glycerol-3-phosphoric acid bromoalkyl esters were reacylated in high yields with fatty acid anhydrides in the presence of perchloric acid. Transformation of the mixed-acid phosphatidic acid bromoalkyl esters to the respective phosphatidyl cholines or -ethanolamines was possible by direct amination.