Synthesis of polysubstituted 1,2-dihydro
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Yangyang Wu; Yihua Zhang; Yongwen Jiang; Dawei Ma
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Article
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2009
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Elsevier Science
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French
β 291 KB
CuI-catalyzed reaction of 1-(2-bromophenyl)-propargylamines 4 with b-keto esters in i-PrOH/H 2 O (3:1) at 50 Β°C provides polysubstituted 1,2-dihydroisoquinolines. The transformation involves a cascade intermolecular C-C bond formation and intramolecular condensation process.