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An efficient synthesis of daidzein, dimethyldaidzein, and isoformononetin

✍ Scribed by Kyle F. Biegasiewicz; Jeffrey D. St. Denis; Vincent M. Carroll; Ronny Priefer

Publisher: Elsevier Science
Year: 2010
Tongue: French
Weight: 298 KB
Volume: 51
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2010.06.078

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✦ Synopsis

Synthesis of the soy isoflavone, daidzein, and its derivatives, isoformononetin and dimethyldaidzein, through utilization of a novel synthetic pathway is reported. This synthesis employs an enamine addition and O-methylation of 2,4-dihydroxyacetophenone, a subsequent ring closure and iodination, followed by a Suzuki coupling with PEG 10000. Demethylation of either isoformononetin or dimethyldaidzein afforded daidzein.

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