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An Efficient Synthesis of an α v β 3 Antagonist

✍ Scribed by Yasuda, Nobuyoshi; Hsiao, Yi; Jensen, Mark S.; Rivera, Nelo R.; Yang, Chunhua; Wells, Kenneth M.; Yau, James; Palucki, Michael; Tan, Lushi; Dormer, Peter G.; Volante, Ralph P.; Hughes, David L.; Reider, Paul J.


Book ID
126973780
Publisher
American Chemical Society
Year
2004
Tongue
English
Weight
172 KB
Volume
69
Category
Article
ISSN
0022-3263

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The cyclic pentapeptide cyclo(-Arg-Gly-Asp-d-Phe-Lys-) is a highly potent and selective inhibitor for the a v b 3 integrin. A related compound, cyclo(-Arg-Gly-Asp-d-Phe-Val-), is a promising anticancer drug candidate; it inhibits angiogenesis and induces apoptosis in vascular cells. We have develope