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An Efficient Synthesis of 6-Nitro- and 6-Amino-3H-imidazo[4,5-b]pyridines by Cyclocondensation of 1-Substituted 1H-Imidazol-5-amines with 3-Nitro-4H-chromen-4-one

✍ Scribed by Ostrovskyi, Dmytro; Iaroshenko, Viktor; Petrosyan, Andranik; Dudkin, Sergii; Ali, Iftikhar; Villinger, Alexander; Tolmachev, Andrei; Langer, Peter


Book ID
125417252
Publisher
Thieme Medical Publishers
Year
2010
Tongue
English
Weight
314 KB
Volume
2010
Category
Article
ISSN
0936-5214

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Convenient syntheses of 5-[(2-methyl-5-n
✍ Javad Mirzaei; Hooshang Pirelahi; Mohsen Amini; Abbas Shafiee πŸ“‚ Article πŸ“… 2008 πŸ› Journal of Heterocyclic Chemistry 🌐 English βš– 268 KB πŸ‘ 1 views

## Abstract magnified image Oxidation of metronidazole (**4**) with sodium dichromate yielded the corresponding 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetic acid (**5**) which was esterified with 1‐butanol to give butyl 2‐(2‐methyl‐5‐nitro‐1__H__‐imidazol‐1‐yl)acetate (**8**). Reaction of the l