An efficient synthesis of 5-benzoyloxazolines by regio- and stereo-controlled reaction of N-substituted 2-benzoylaziridines under microwave irradiation

✍ Scribed by Heshmat A. Samimi; Manouchehr Mamaghani; Khalil Tabatabaeian

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2008
• Tongue: English
• Weight: 317 KB
• Volume: 45
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570450632

✦ Synopsis

Abstract

magnified image

Several N‐acyl‐2‐benzoylaziridines were prepared conveniently in good to high yields (71‐93%) and used in the preparation of 5‐benzoyloxazolines (76‐91%) by a regio‐ and stereo‐controlled reaction in the presence of Nal as an efficient catalyst under microwave irradiation in short reaction times (5‐10 mins). The structure of the regioisomeric product was confirmed by X‐ray analysis.