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An efficient synthesis of 3-alkyl-1,5,3-dioxazepanes and their use as electrophiles in double-Mannich reactions

✍ Scribed by Kevin Sparrow; David Barker; Margaret A. Brimble


Book ID
113929177
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
886 KB
Volume
68
Category
Article
ISSN
0040-4020

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## Abstract The double Mannich reaction of cyclic β‐keto esters with bis(alkoxymethyl)alkylamines provides an efficient and versatile method for the construction of azabicyclo[3.3.1]nonanes and azabicyclo[3.2.1]octanes. The optimum conditions for efficient reaction involve use of the activator tric