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An efficient synthesis of 2,3-diaryl-2-azabicyclo[2.2.2]octan-5-ones and their acetylcholinesterase inhibitory activity

โœ Scribed by Huang, Li; Chen, Jun-Pei; Jin, Can; Su, Wei-Ke

Book ID
120312402
Publisher
Chinese Electronic Periodical Services
Year
2013
Tongue
English
Weight
454 KB
Volume
24
Category
Article
ISSN
1001-8417

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A series of 1-azabicyclo[2.2.2]octan-3-one oximes and related 1-azabicyclo-[2.2.2]-octan-3-one hydroxylamines were synthesized and tested for muscarinic M3 activity. All compounds showed at least some muscarinic binding properties, however, only one member of the series demonstrated mucarinic M3 ago