Synthesis and antibacterial activity of
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Hans Rudolf Pfaendler; Claus Medicus
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Article
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1997
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Elsevier Science
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English
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As with the oxapenems, the 2-tert-butyl substituents substantially increased the hydrolytic stability of penems. The corresponding penems 1 and 2 were prepared and found to be extremely stable compounds. 2 showed good in vitro activity against gram-positive bacteria.