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An efficient synthesis of 2-substituted-thio-6-hydroxyethyl-penem-3-carboxylic acids via 2-thioxopenams

โœ Scribed by W.J. Leanza; Frank DiNinno; David A. Muthard; R.R. Wilkening; Kenneth J. Wildonger; R.W. Ratcliffe; B.G. Christensen


Book ID
108372812
Publisher
Elsevier Science
Year
1983
Tongue
French
Weight
987 KB
Volume
39
Category
Article
ISSN
0040-4020

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As with the oxapenems, the 2-tert-butyl substituents substantially increased the hydrolytic stability of penems. The corresponding penems 1 and 2 were prepared and found to be extremely stable compounds. 2 showed good in vitro activity against gram-positive bacteria.